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Insights and Expertise


                          Online healthcare commerce:


                                  A prescription for risk?




                                                                against violative models, developments that directly affect
                                                                e-commerce platforms and payment service providers. At
                                                                the same time, rising demand has created new opportu-
                                                                nities for illicit sellers. For example, "peptide" merchants
                                                                were once niche operators catering largely to bodybuild-
                                                                ers. Now, they market products—including GLP-1 drugs
                                                                and popular "biohacking" compounds like BPC-157—di-
                                                                rectly to mainstream consumers.

                                                                These products are often labeled "for research purposes
                                                                only" and "not for human consumption," disclaimers in-
                                                                tended to sidestep regulatory scrutiny. In practice, how-
                                                                ever, regulators assess such products based on how they
        By Niamh Lewis                                          are marketed and used. Many peptide sellers openly pitch
        G2 Risk Solutions                                       their products for consumer use—through social media
                                                                advertising,  influencer  marketing,  and  online  forums—
                 he digital health economy is booming.          despite the disclaimers on their labels.
                 Telehealth platforms, online marketplaces, and
                 cross-border fulfillment networks have made    Key areas where risk hides
        T it possible to obtain everything from prescrip-       The challenge doesn't just lie in identifying known bad
        tion medications to dietary supplements with a few      actors. E-commerce and payment services professionals
        clicks. However, that convenience has also led to rapidly   must gain a big-picture understanding of where and how
        rising risk for platforms and payment providers.  At the   risk manifests before they onboard sellers.
        intersection of e-commerce and consumer demand for
        wellness products, a complex threat landscape is taking   Here are some of the critical areas identified by risk
        shape. Surging demand for GLP-1 weight loss drugs, psy-  analysts:
        choactive compounds, and tainted supplements is creat-
        ing opportunities for illicit sellers to exploit gaps across   •  Potentially tainted supplements: Supplements con-
        e-commerce, payments, and regulatory systems.                taining undeclared substances are a global problem.
                                                                     When tested by regulators, many products are found
        For these reasons, online healthcare commerce has be-        to contain potentially dangerous, or even prescrip-
        come one of the most complex and consequential risk cat-     tion-only, ingredients. Certain categories of supple-
        egories in digital commerce. Understanding the risks isn't   ments, such as those marketed for sexual enhance-
        just about compliance; it's about consumer safety.           ment, weight loss or bodybuilding, are particularly
        Demand for wellness products is                              prone to issues.
        reshaping the threat landscape                               When consumers purchase supplements, they often
                                                                     think they are taking something natural. In reality,
        At the center of the digital health risk landscape is a ris-  some products marketed as supplements may con-
        ing wave of consumer demand. For example, GLP-1 drugs,       tain prescription-only ingredients, sometimes at dos-
        known under brand names such as Ozempic, Wegovy,             es several times higher than approved drugs. For ex-
        Mounjaro, and Zepbound, have become one of the fastest-      ample, the FDA flagged more than two dozen honey-
        growing drug categories in history.                          based products (see https://tinyurl.com/2tdhy6xm)
                                                                     for containing hidden drug ingredients (such as
        An estimated 12 percent of U.S. adults (see https://tinyurl.  sildenafil and tadalafil, the active ingredients in Vi-
        com/5fpaf7m4) have used some form of GLP-1 therapy, and      agra and Cialis).
        global sales are projected to reach $150 billion (see https://
        tinyurl.com/2k6dab8b) by the early 2030s. In addition, many   As with other high-risk supplements, social media
        Americans pay out of pocket, making these drugs particu-     attention and word-of-mouth can accelerate demand,
        larly attractive to digital-first sellers. An entire ecosystem   even when consumers do not realize what they are
        has emerged around demand for these drugs. Direct-to-        ingesting (see https://tinyurl.com/45n4zdyf).
        consumer tele-health models, compounding pharmacies,         The challenge is that tainted products often appear
        and med spas sit adjacent to traditional brick-and-mortar    alongside otherwise legitimate inventory. A single
        clinics and pharmacies. As access to GLP-1 medications       high-risk supplement may be sold by a third-party
        expands,  regulators have increased enforcement  actions
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